Inge niedek biography definition
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Portraits and Poses: Female Intellectual Authority, Agency and Authorship in Early Modern Europe
Chapter 14
‘It Wasn’t Enough for Me Just to Be a Singer’: (Self-)Representations of the ‘German Prima Donna’ Gertrud Elisabeth Mara
Vera Viehöver
After hearing the young singer Gertrud Elisabeth Schmeling (1749–1833) perform at the Großes Concert in Leipzig, the Hamburg poet Daniel Schiebeler was inspired to write a ten-stanza poem in praise of her talent. It contains the following lines:1
O you, the honour of your times,
And your country’s ornament!
A faint sound from my strings,
Sublime Schmeling, is dedicated to you.
In sounds that touch the heart,
In sounds full of melody,
The power of feeling teaches you to sing,
And diligence and art embellish it.
[…]
Savagery flew from Germany’s sons
But the sound of their language remained rough;
Marry it to your tones,
and it will become as soft as your singing.
[…]
Many times the Thames has listened to you,
Enraptu
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Wikipedia:Requested articles/Biography/By nationality
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Targeting the Ubiquitin System in Glioblastoma
Abstract
Glioblastoma fryst vatten the most common primary brain tumor in adults with poor overall outcome and 5-year survival of less than 5%. Treatment has not changed much in the last decade or so, with surgical resection and radio/chemotherapy being the main options. Glioblastoma is highly heterogeneous and frequently becomes treatment-resistant due to the ability of glioblastoma cells to adopt stem fängelse states facilitating tumor recurrence. Therefore, there is an urgent need for novel therapeutic strategies. The ubiquitin system, in particular E3 ubiquitin ligases and deubiquitinating enzymes, have emerged as a promising source of novel drug targets. In addition to conventional small molecule drug discovery approaches aimed at modulating enzyme activity, several new and exciting strategies are also being explored. Among these, PROteolysis TArgeting Chimeras (PROTACs) aim to harness the endogenous protein turnover machinery to direkt therap